سانچہ:PBB/دستاویز

	Breast cancer 1, early onset
	Available structures: 1jm7, 1jnx, 1n5o, 1oqa, 1t15, 1t29, 1t2u, 1t2v, 1y98
	شناختساز
Symbols	BRCA1; BRCAI; BRCC1; IRIS; PSCP; RNF53
بیرونی شناختیں	OMIM: 113705 MGI: 104537 HomoloGene: 5276
وراثی وجودیات
Molecular function:	• molecular_function; • DNA binding; • damaged DNA binding; • transcription coactivator activity; • ubiquitin-protein ligase activity; • protein binding; • zinc ion binding; • tubulin binding; • enzyme binding; • metal ion binding; • androgen receptor binding;
Cellular component:	• ubiquitin ligase complex; • condensed chromosome; • cellular_component; • intracellular; • nucleus; • cytoplasm; • gamma-tubulin ring complex; • BRCA1-BARD1 complex;
Biological process:	• cell cycle checkpoint; • DNA replication; • DNA repair; • regulation of transcription from RNA polymerase II promoter; • regulation of transcription from RNA polymerase III promoter; • fatty acid biosynthetic process; • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; • cell cycle; • chromosome segregation; • centrosome cycle; • DNA damage response, signal transduction resulting in induction of apoptosis; • dosage compensation, by inactivation of X chromosome; • negative regulation of transcription; • protein ubiquitination; • androgen receptor signaling pathway; • positive regulation of protein ubiquitination; • regulation of cell proliferation; • regulation of apoptosis; • negative regulation of fatty acid biosynthetic process; • positive regulation of DNA repair; • negative regulation of progression through cell cycle; • positive regulation of transcription, DNA-dependent; • negative regulation of centriole replication;
	RNA expression pattern
	More reference expression data
	منتصبات

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